Intra-articular administration of hydrogen sulphide ameliorates severity of experimental osteoarthritis

Therapeutic Effects of Intra-Articular Ultrapurified Low Endotoxin Alginate Administration on Experimental Osteoarthritis in Rabbits

OBJECTIVE We have developed an ultrapurified low endotoxin alginate (UPLE alginate), which can drastically reduce endotoxin levels. Our purposes were to examine the effects of UPLE alginate administration on osteoarthritis (OA) progression and to determine the adequate molecular weight of the UPLE alginate for therapeutic effects. DESIGN To induce knee OA, 35 Japanese White rabbits underwent ...

Intra-articular therapy in osteoarthritis.

The medical literature was reviewed from 1968-2002 using Medline and the key words "intra-articular" and "osteoarthritis" to determine the various intra-articular therapies used in the treatment of osteoarthritis. Corticosteroids and hyaluronic acid are the most frequently used intra-articular therapies in osteoarthritis. Other intra-articular substances such as orgotein, radiation synovectomy,...

Effects of intra-articular hyaluronic acid and corticosteroid therapies on articular cartilage in experimental severe osteoarthritis.

Therapeutic Benefit of Intra-articular Administration of Deciduous Teeth Stem Cells in Rabbit Model of Osteoarthritis

Background and Objective: Stem cell therapy is a new treatment option for osteoarthritis. A various applications of stem cell therapy have been used for cartilage regeneration in arthritis patient. The objective of this study was to examine therapeutic effects of puppy deciduous teeth stem cells for the treatment of osteoarthritis using a rabbit model. Methodology: In this study, rabbits were s...

Therapeutic effects of intra-articular ultra-purified low endotoxin alginate administration on an experimental canine osteoarthritis model.

OBJECTIVE This study aimed to elucidate the therapeutic effects of intra-articular administration of ultra-purified low endotoxin alginate (UPLE-alginate) on osteoarthritis (OA) using a canine anterior cruciate ligament transection (ACLT) model. DESIGN We used 20 beagle dogs. ACLT was performed on the left knee of each dog and a sham operation was performed on the right knee as a control. All...